The large GTPase dynamin is essential for clathrin-dependent coated-vesicle development. Dynasore is a cell-permeable tiny molecule that inhibits the GTPase exercise of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a very screen of ~16,000 compounds for inhibitors on the dynamin2 GTPase.Discovery and pharmacolog